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[edit] Discussion

[edit] Imaging Findings

[edit] Skeletal

• Marrow proliferation consists of expansion of the medulla, thinning of cortical bone, and resorption of cancellous bone: results in a generalized loss of bone density
• Skull: Classic "hair-on-end" appearance.
• Facial bones: Rodent facies
• Ribs: "Rib-within-a-rib" appearance, noted particularly in the middle and anterior portions of the ribs.
• Extramedullary hematopoiesis
• Premature fusion of the epiphyses

[edit] GI/GU

• Cholelithiasis
• Hemosiderosis

[edit] Images

Patient #1

Patient #2

[edit] See Also

• Sickle cell disease

[edit] External Links

• Goldminer: Thalassemia

[edit] References

e-medicine.com