In-111 ProstaScint

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[edit] Full name

capromab pendetide

[edit] Photon energy

173, 247 keV

[edit] Uses, dosages, and Time of Imaging

  • Prostate cancer
  • 5 mCi IV
  • 30 min (blood pool) and then 3 days

[edit] Physical half life

67 hours

[edit] Biological half life

72 hours

[edit] Normal distribution

Liver, spleen, bone marrow, blood pool structures, bowel, bladder

[edit] Pharmacokinetics

Monoclonal Ab reactive with prostate-specific membrane antigen (PMSA) which is expressed by more than 95% of prostate cancer

[edit] Excretion

[edit] Target organ

Liver, spleen, kidneys

[edit] Other

  • Indicated for bx-proven cancer thought to be localized but high risk for pelvic LN mets
  • Suspected occult mets after prostatectomy with rising PSA
  • Se 62% for LN mets (CT 4%, MRI 15%); Sp 72%