Infantile hemangioendothelioma

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[edit] Discussion of Infantile hemangioendothelioma

  • Infantile hemangioendotheliomas are liver lesions composed of large endothelial-lined vascular channels
  • Histologically distinct from hemangioma.
  • Hemangioendotheliomas have been detected in utero as early as 16 weeks gestation.
  • Substantial arteriovenous shunting may lead to fetal cardiovascular compromise and hydrops.
  • In addition, fetuses may also develop hemolytic anemia, thrombocytopenia, and consumptive coagulopathy (Kasabach-Merritt sequence).
  • If these tumors are not detected prenatally, neonates may present with unexplained congestive heart failure.

  • The natural history of hemangioendotheliomas in infancy is a rapid, proliferative growth phase in the first 6 months of life, followed by regression and involution.
  • If the child remains asymptomatic, no treatment may be needed.
  • If symptoms occur, the first line of treatment is corticosteroids, which are thought to cause vasoconstriction of the aberrant vessels.

[edit] Imaging Findings for Infantile hemangioendothelioma

  • Infantile hemangioendotheliomas have a variable sonographic appearance and may be either hypoechoic or hyperechoic or may have mixed echogenicity.
  • Color Doppler US evaluation will show increased flow.

[edit] Images

Patient #1

[edit] External Links

[edit] References for Infantile hemangioendothelioma