Meconium ileus

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[edit] Discussion of Meconium ileus

  • Meconium found in the intestine of a newborn, consisting of succus entericus (bile salts, bile acids, and debris from the intestinal mucosa)
  • Meconium is normally evacuated within 6 hours of birth or earlier.
  • Meconium ileus occurs with meconium becomes inspissated and obstructs the distal ileum.
  • Usually a manifestation of cystic fibrosis. Usually understood as synonymous with cystic fibrosis until proven otherwise.
  • Approximately 20% of infants with cystic fibrosis present with meconium ileus at birth.
  • May also be seen with pancreatic atresia or stenosis of the pancreatic duct.
  • May rarely occur without cystic fibrosis or pancreatic abnormality in cases likely related to gut immaturity (more favorable outcome)
  • Further complications include ileal atresia or stenosis, ileal perforation, meconium peritonitis, and volvulus with or without pseudocyst formation.
  • More common in white populations.
  • Affects both sexes almost equally.

[edit] Imaging Findings for Meconium ileus

  • Prenatal ultrasound findings associated with meconium ileus include polyhydramnios, fetal ascites, peritoneal wall calcifications, and intraabdominal cysts.
  • Meconium is normally invisible radiographically.
  • Occassionally, has a mottled appearance on radiographs during the first 2 days of life.
  • Classically, a paucity or absence of air-fluid levels and a "bubbly" appearance of distended intestinal loops on radiographs.
  • Microcolon seen on barium enema.
  • Characteristic findings often not seen, and thus relatively unreliable.

[edit] Images

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[edit] See Also

[edit] External Links

[edit] References for Meconium ileus

  • Denholm, T.A., Crow, H.C., Edwards, W.H., Simmons, G.M., Marin-Padilla, M., and Bartrum, R.J. Prenatal sonographic appearance of meconium ileus in twins. AJR, 1984; 143: 371-372.
  • Leonidas, J.C., Berdon, W.E., Baker, D.H., and Santulli, T.V. Meconium ileus and its complications: a reappraisal of plain film roentgen diagnostic criteria. American Roentgen Ray Society, 1970.
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