Discussion of Osteopoikilosis
- Osteopoikilosis is AKA osteopathia condensans disseminata and "spotted bone disease"
- Osteopoikilosis is an asymptomatic disorder
- Characterized by an abnormality in the enchondral bone maturation process that results in numerous round 2-10 mm bone islands, that are symmetrically distributed within the metaphyses and epiphyses of the long bones,
- Lesions appears in childhood and persists throughout life.
- It may either be inherited in an autosomal dominant fashion or occur sporadically.
- Men and Women are equally affected.
- Sites of predilection include hands, feet, pelvis, and femur.
- The ribs, skull and vertebrae are typically spared.
- Some patients have connective tissue nevi called dermatofibrosis lenticularis disseminata.
- Osteopoikilosis have also been found to be associated with a tendency to keloid formation, dwarfism, spinal stenosis, dystocia, melorheostosis, tuberous sclerosis and scleroderma.
- Its major clinical significance is that it should not be confused with metastatic osteoblastic lesions.
 Imaging Findings for Osteopoikilosis
- On radiography, small, well-defined, ovoid foci of increased radio density are clustered in periarticular osseous regions.
 See Also
 External Links
 References for Osteopoikilosis
- Karwar, J, Gupta, R, and Sharma, G. Osteopoikilosis: A case report. Indian Journal of Radiology and Imaging. 2005 15: 453-454.