Pseudoangiomatous stromal hyperplasia

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[edit] Discussion of Pseudoangiomatous stromal hyperplasia

  • Pseudoangiomatous stromal hyperplasia (PASH) is a benign proliferative lesion of mammary stroma
  • Contains complex anastomosing spaces that may be confused with angiosarcoma at histologic analysis.
  • It represents a clinicopathologic spectrum ranging from focal, incidental microscopic findings to clinically and mammographically evident breast masses.
  • PASH is a relatively common incidental finding at breast biopsy (Ibrahim et al reported 23%).

  • The tumoral form of PASH (clinically and mammographically evident breast masses) is rare.
  • Tumoral PASH has frequently been misdiagnosed at clinical examination as a fibroadenoma.
  • The tumoral form of PASH most commonly manifests as a single, circumscribed, palpable mass in a premenopausal female. The mass is usually large (5–6 cm in diameter), with reported diameters ranging from 1 to 12 cm.
  • Although mass lesions in PASH often grow over time and may recur after excisional biopsy, they are neither associated with malignancy nor considered to be premalignant lesions.

[edit] Imaging Findings for Pseudoangiomatous stromal hyperplasia

  • At mammography, masses due to PASH are usually non-calcified and appear well circumscribed or partially circumscribed.
  • The masses are seen at US as hypoechoic solid masses and echotexture may be slightly heterogeneous.

[edit] Images

Patient #1

[edit] See Also

[edit] External Links

[edit] References for Pseudoangiomatous stromal hyperplasia