Renal medullary carcinoma

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[edit] Discussion of Renal medullary carcinoma

  • Renal medullary carcinoma is a recently described highly aggressive malignant tumor
  • Epithelial origin
  • Occurs almost exclusively in adolescent and young adult blacks with sickle cell trait or hemoglobin SC disease but not with homozygous hemoglobin SS sickle cell disease.
  • Termed the seventh sickle cell nephropathy.
  • Age range is 10–39 years with a mean age of 20 years.
  • Presenting symptoms include gross hematuria, abdominal or flank pain, and less commonly weight loss, a palpable mass, or fever.
  • Renal medullary carcinoma is thought to arise at the renal pelvic-mucosal interface.
    • The tumor quickly grows to fill the renal pelvis and invade vascular and lymphatic structures.
    • Intraparenchymal satellite nodules are frequently present.

[edit] Imaging Findings for Renal medullary carcinoma

  • Imaging demonstrates a centrally located infiltrative lesion invading the renal sinus with peripheral caliectasis, reniform enlargement, and smaller peripheral satellite nodules.
  • There is heterogeneous enhancement at CT, and US shows heterogeneous echotexture.
  • The differential diagnosis includes transitional cell carcinoma which is exceedingly rare and poorly documented in children and rhabdoid tumor.

[edit] Images

Patient #1

[edit] See Also

[edit] External Links

[edit] References for Renal medullary carcinoma