Renal medullary carcinoma
 Discussion of Renal medullary carcinoma
- Renal medullary carcinoma is a recently described highly aggressive malignant tumor
- Epithelial origin
- Occurs almost exclusively in adolescent and young adult blacks with sickle cell trait or hemoglobin SC disease but not with homozygous hemoglobin SS sickle cell disease.
- Termed the seventh sickle cell nephropathy.
- Age range is 10–39 years with a mean age of 20 years.
- Presenting symptoms include gross hematuria, abdominal or flank pain, and less commonly weight loss, a palpable mass, or fever.
- Renal medullary carcinoma is thought to arise at the renal pelvic-mucosal interface.
- The tumor quickly grows to fill the renal pelvis and invade vascular and lymphatic structures.
- Intraparenchymal satellite nodules are frequently present.
 Imaging Findings for Renal medullary carcinoma
- Imaging demonstrates a centrally located infiltrative lesion invading the renal sinus with peripheral caliectasis, reniform enlargement, and smaller peripheral satellite nodules.
- There is heterogeneous enhancement at CT, and US shows heterogeneous echotexture.
- The differential diagnosis includes transitional cell carcinoma which is exceedingly rare and poorly documented in children and rhabdoid tumor.
 See Also
 External Links
 References for Renal medullary carcinoma
- Lisa H. Lowe, Bernardo H. Isuani, Richard M. Heller, Sharon M. Stein, Joyce E. Johnson, Oscar M. Navarro, and Marta Hernanz-Schulman. Pediatric Renal Masses: Wilms Tumor and Beyond. RadioGraphics 2000 20: 1585-1603.