Splenic hamartoma

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[edit] Discussion of Splenic hamartoma

  • AKA splenomas, splenadenomas, or nodular hyperplasia of the spleen
  • Rare benign lesions
  • Autopsy series has shown that the incidence of splenic hamartoma ranges from 0.024% to 0.13%
  • Hamartomas may occur at any age with equal gender predilection.
  • Most patients have no symptoms, and the discovery of a splenic hamartoma is an incidental finding.
  • Larger lesions may manifest with a palpable mass, splenomegaly, or rupture.
  • Thrombocytopenia and anemia may occur from sequestration of hematopoietic cells.
  • Hamartomas of the spleen have been associated with hamartomas elsewhere in the body and have been reported in cases of tuberous sclerosis.
  • The importance of imaging splenic hamartomas lies in the need to differentiate them from malignant lesions of the spleen such as lymphoma and metastasis.

[edit] Imaging Findings for Splenic hamartoma

  • Sonography appears to be more sensitive than CT.
  • On sonograms, splenic hamartomas are typically solid homogeneous masses. Most hamartomas are hyperechoic relative to the adjacent normal splenic parenchyma. On color Doppler images, these lesions often demonstrate increased blood flow.
  • On angiograms, a splenic hamartoma appears as a hypervascular mass consisting of tumor vessels with aneurysmal dilatation, arteriovenous shunts, vascular lakes, and tumor blush resembling a typical malignant vascular pattern.
  • On CT scans, hamartomas often appear nearly isoattenuating relative to normal spleen before and after intravenous administration of contrast material and, therefore, can be difficult to detect.
  • On MRI, splenic hamartomas are isointense relative to normal splenic parenchyma on T1-weighted MR images, heterogeneously hyperintense on T2-weighted MR images, and heterogeneously diffusely enhanced on T1-weighted MR images obtained immediately after gadolinium injection. On delayed MR images, hamartomas were shown to have a more uniform homogeneous pattern of enhancement.

[edit] Images

Patient #1

[edit] See Also

[edit] External Links

Goldminer: Splenic hamartoma

[edit] References for Splenic hamartoma